Cleveland State University

Director:	Address:
David Anderson, PhD, DABCC Telephone: (216) 687-2453 Fax: (216) 687-9298 E-mail: d.anderson@popmail.csuohio.edu	Department of Chemistry Cleveland State University 2351 Euclid Avenue Cleveland, OH 44115-2440

Affiliated Institutions: Cleveland Clinic Foundation, MetroHealth Medical Center

Faculty and Research Interests

Cleveland State University: Department of Chemistry
David Anderson, PhD, DABCC	HPLC and mass spectrometry of proteins, proteomics
Mekki Bayachou, PhD	Biosensors and bioelectrochemistry applied to cytochrome p450, nitric oxide synthase, and DNA interactions (with anti-tumor agents, antibiotics, regulatory proteins)
Valentin Gogonea, PhD	Computational chemistry, molecular modeling of proteins and macromolecules, including nitric oxide synthase and hydrogenase, and high density lipoproteins
Baochuan Guo, PhD	Mass spectrometry of proteins, DNA, and bile acids; mass spectrometric immunoassays
Michael Kalafatis, PhD	Biochemistry of blood coagulation and thrombosis; biochemistry of cancer, including phosphorylation and identification of proteins involved in cell proliferation
Bin Su, PhD	Medicinal chemistry, developing new drugs for ER+ and Her2 breast cancers
Xue-Long Sun, PhD	Bioanalytical, pharmaceutical and medicinal chemistry. Glyco-affinity techniques applied to proteomics, glycomics, and targeted drug delivery; cytomimetic antithrombotics; cellular chemistry.
John Turner, II, PhD	Biomedical imaging, multivariate analysis and spectroscopy applied to analysis of sub-micron architecture of tissues and cells, biomaterial implants, artificial cell scaffolds, and diagnosis of pre-cancerous lesions
Robert Wei, PhD, DABCC	Environmental pathology, free radicals
Yan Xu, PhD	Capillary electrophoresis, immunoassays, and mass spectrometry in bioanalysis; pharmacokinetic and pharacodynamic endpoints of novel therapeutic agents; development of anti-tumor drugs
Aimin Zhou, PhD	RNAse L biochemistry in infectious diseases, cancer, cardiovascular disease, diabetes, inflammatory conditions, apoptosis and cell signaling. Disease marker discovery.
Cleveland Clinic: Department of Clinical Pathology
Manjula K. Gupta, PhD	Endocrine aspects of prostate and breast cancer, RT-PCR detection of circulating tumor cells, autoimmune endocrine disorders
Sihe Wang, PhD, DABCC	HPLC, LC-MS, ICP-MS, cardiac markers, kidney function, nutrition assessment, and TDM and clinical toxicology.
Cleveland Clinic: Lerner Research Institute
Alex Almasan, PhD	Genotoxic stress-induced signals for cell control, cell death, and survival. DNA damage in tumors, Apo2L/TRAIL in apoptosis signaling and cancer therapy
Kathleen Berkner, PhD	Vitamin K-dependent protein carboxylation
Martha Cathcart, PhD	Human monocyte activation, inflammation, regulation of NADPH oxidase generation of superoxide anion, lipid oxidation, expression of 15-lipoxygenase, signal transduction, regulation of monocyte chemotaxis to MCP1
Guy Chisolm, III, PhD	Lipoprotein oxidation in inflammation and atherosclerosis, intracellular signaling events of apoptosis in vascular cells, genetically altered mouse models of vascular disease
John Crabb, PhD	Mass spectrometry in proteomics, age-related macular degeneration, primary open angle glaucoma
Paul DiCorleto, PhD	Vascular endothelial cell gene expression and regulation in atherosclerosis. TNF-a Signaling, role of Homeobox Gene HOXA9, MAP Kinase Phosphatase-1 in EC signaling
Donna Driscoll, PhD	Post-transcriptional regulation of gene expression, selenocysteine
Serpil Erzurum, MD	Airway inflammation and host defense, reactive oxygen and nitrogen species in lung disease, pulmonary vascular endothelium and angiogenesis, asthma, pulmonary hypertension
Maria Febbraio, PhD	Role of CD36 in atherosclerosis, macrophage biology, diabetes, fatty acid metabolism
Paul Fox, PhD	Translational control of inflammatory gene expression, endothelial cell migration, macrophage iron metabolism
Ram Ganpathi, PhD	Clinical pharmacology and experimental cancer chemotherapy
Saikh Jaharul Haque, PhD	Cytokine-mediated cell signaling in health and disease, particularly in allergic inflammation and brain cancer
Stanley Hazen, MD, PhD	Mass spectrometry in biomedical research. Mechanisms of atherosclerosis; leukocyte peroxidases; nitric oxide and reactive oxygen species; oxidant injury in asthma and other inflammatory diseases; cardiovascular genetics
Donald Jacobsen, PhD	Cardiovascular disease, homocysteine metabolism, endothelial cell function, cobalamin and folate biochemistry
Sadashiva Karnik, PhD	GPCR structure-function, signal transduction, cell growth. Ang II receptor function and cell death of Ang II expressing cells. Chromation remodeling changes induced by Ang II receptors
Xiaoxia Li, PhD	Signal transduction in innate and adaptive immunity
Thomas McIntyre, PhD	Lipid mediators and their role in apoptosis, inflammation, platelet function, and aging
Richard Padgett, PhD	Mechanisms of RNA splicing in vivo and in vitro
Edward Plow, PhD	Molecular mechanisms of cell adhesion and migration. Integrins, platelets, protease receptors, plasminogen, fibronection
Jun Qin, PhD	Biomeolecular NMR spectroscopy, protein-protein and protein-nucleic acid interactions, signal transduction
Robert Silverman, PhD	Innate defense against viruses and cancer. Antiviral mechanisms of RNase L, role of RNase L in the biology of prostate cancer, broad-spectrum antivirals that activate RNase L, XMRV infections in prostate cancer
Roy Silverstein, MD	Vascular biology, including thrombosis, angiogenesis, atherosclerosis, and inflammation; CD36 and TSR- containing proteins
Jonathan Smith, PhD	The pathobiology and genetics of atherosclerosis and atrial fibrillation, and the mechanisms involved in reverse cholesterol transport. ApoA1 variants, pathways in the cholesterol uptake by macrophages. Microarrays and bioinformatics.
George Stark, PhD	Signal transduction pathways involving interferons, STATs, NFKB, p53 and TGF ß ; methods for forward genetics in mammalian cells
Dennis Stuehr, PhD	Structure and biochemistry of nitric oxide synthases and related enzymes
Bruce Trapp, PhD	Cellular and molecular biology of myelination, demyelination, and dysmyelination
Qing Wang, PhD	Microarray analysis, genetics and molecular biology of diseases, gene expression, developmental biology of the heart and blood vessels
MetroHealth Medical Center: Department of Pathology
Michael Ip, PhD, DABCC	Troponin I and myoglobin in cardiac diagnosis GGT and AFP variants in the diagnosis of hepatocellular carcinoma

Program Listing:

Levels of training:

Number of positions available per year:

Duration of program:

Approximate annual salary or stipend

Source of funding:

Current number of trainees:

Number of past graduates (over last 7 years)

PhD

Varies

4-6 years for PhD

$17,000 – 18,500 stipend and tuition waiver

Teaching and research assistantships

9 PhDs

Applicant Procedures:

Prerequisites:

BS in chemistry, biology, medical technology or related degree; GRE; TOEFL (if degree is from an institution outside of the United States); and two letters of recommendation are required.

Applicants must have had one year of general, organic, analytical, and one semester of physical chemistry. Applicants lacking any of these requirements may be admitted, but any deficiency must be made up as soon as possible.

Typically, applicants are required to submit an official report of their performance on both the aptitude and chemistry subject area tests from the Graduate Record Examination (GRE) to the University by the Educational Testing Service (ETS). However, applicants with outstanding records (grade-point average above 3.0 in addition to other evidence of solid preparation) may request that this requirement be waived by the Graduate Committee of the Chemistry Department. The GRE requirement cannot be waived for international students. International students who do not have a degree from an institution in the United States must also arrange to have the results of their performance on the TOEFL sent to the University by ETS.

Procedures:

Applications can be mailed in or submitted on-line. The application process, paperwork to submit, and how to submit is given on the website: http://www.csuohio.edu/gradcollege/admissions/degree.html

The application deadline each year is January 15 for applicants requesting financial support (graduate assistantships that include stipend and tuition). This is for admittance and financial support starting for the subsequent fall semester. Applications not considered for financial aid can be received up until the end of June, for a fall semester admittance, and up until the end of November, for a spring semester admittance.

Questions about the application process should be directed to Ms. Richelle Emery, Administrative Coordinator in the Department of Chemistry (216-687-2457, r.emery@csuohio.edu).

Program Description:

The doctoral graduate program in Clinical Chemistry is a dynamically integrated program merging the fields of biomedicine, clinical diagnosis, and analytical chemistry. The program is jointly administered by Cleveland State University and The Cleveland Clinic, in affiliation with MetroHealth Medical Center. In addition, other Cleveland medical centers actively participate. The Clinical Chemistry program gives rigorous instruction in all aspects of disease processes, with in-depth coverage given for testing strategies and methodologies used in disease diagnosis. PhD graduates are trained as directors of clinical laboratories (in hospitals, medical centers, and reference laboratories) and as laboratory scientists in the in-vitro diagnostics, biotechnology and pharmaceutical industries.

PhD Clinical Chemistry students take one year of clinical chemistry (two 4 semester credit courses), one year of advanced biochemistry (two 4 semester credit courses), one laboratory course in biotechnology techniques (4 semester credits), one chemistry elective course (3-4 semester credits), four courses of special topics in clinical chemistry (1 semester credit each) and an internship course in the clinical laboratory (6 semester credits). An optional second internship in the clinical laboratory (6 semester credits) can be taken. Each internship course encompasses a 6 week rotation in a medical center clinical laboratory, where the student learns the principles and practice of clinical laboratory testing. The student may also work on developmental projects in the internship courses. The second internship course gives experience in specialized clinical laboratory techniques.

Dissertation research is an important component of the Clinical Chemistry PhD degree. PhD students begin earnest work on their dissertation research at the start of their second year. Graduate students must pass a Ph.D. Candidacy Examination at the beginning of their third year of graduate studies to be officially in the PhD program. The examination consists of the preparation of an acceptable, written, fully referenced proposal, describing the student’s research plans and an oral presentation and committee examination. Ph.D. students must complete at least ninety credit hours of approved course work (including CHM 899 Ph.D. Dissertation) and successfully defend a doctoral dissertation.

Students do research at state-of-the-art facilities at Cleveland State University, The Cleveland Clinic, and other medical centers. The program includes over 40 faculty members who collectively have a broad range of research interests in the fields of disease mechanisms and diagnosis, bioanalytical chemistry, biomedicine, and molecular biology. Cutting-edge bioanalytical technologies used in research include; mass spectrometry (including MALDI-TOF, quadrupole, qtrap, ion trap, quadrupole-TOF), HPLC, conventional and capillary electrophoresis, immunoassays, ultracentrifugation, NMR, EPR, FTIR, absorption spectrophotometry, spectrofluorometry, X-ray crystallography, molecular biology techniques, computational chemistry, biosensors, microarray techniques, etc.